TUBB anticorps (C-Term)

N° du produit ABIN1112713

Cet anticorps Souris Monoclonal détecte spécifiquement TUBB dans WB et IF. Il présente une réactivité envers Souris, Rat, Singe, Chien et Hamster.

Aperçu rapide pour TUBB anticorps (C-Term) (ABIN1112713)

Antigène: TUBB (Tubulin, beta (TUBB))

Reactivité: Souris, Rat, Singe, Chien, Hamster

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TUBB est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Détail du produit anti-TUBB anticorps

Épitope: C-Term

Specificité: Detect the endogenous levels of total beta-Tubulin protein.

Immunogène: Protein fragment on C-terminal of human beta-Tubulin.

Isotype: IgG1

Information d'application

Indications d'application: Western Blot (1:5000), Immunofluorescence(1:1000) .Other applications have not been tested. The optimal dilutions should be determined by end user.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide, Thimerosal (Merthiolate)

Stock: -20 °C

Stockage commentaire: Store at -20 °C for 1 year. Avoid repeated freeze and thaw cycles.

Date de péremption: 12 months

Détails sur TUBB

Antigène: TUBB (Tubulin, beta (TUBB))

Autre désignation: beta-Tubulin

Sujet: Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are alpha-tubulin and beta-tubulin, the proteins that make up microtubules. Each has a molecular weight of approximately 55 kiloDaltons. Microtubules are assembled from dimers of alpha- and beta-tubulin. These subunits are slightly acidic with an isoelectric point between 5.2 and 5.8. 1 Mutant huntingtin, disrupted intracellular transport and insulin secretion by direct interference with microtubular beta-tubulin. Mutant huntingtin impaired glucose-stimulated insulin secretion in insulin-producing beta cells, without altering stored levels of insulin. Smith et al. (2009) proposed a novel pathogenetic process by which mutant huntingtin may disrupt hormone exocytosis from beta cells and possibly impair vesicular transport in any cell that expresses the pathogenic protein. 2

Pathways: Dynamique des Microtubules, M Phase